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Cobalt chelatase () is an enzyme that catalyzes the chemical reaction :ATP + hydrogenobyrinic acid a,c-diamide + Co2+ + H2O ADP + phosphate + cob(II)yrinic acid a,c-diamide + H+ The 4 substrates of this enzyme are ATP, hydrogenobyrinic acid a,c-diamide, Co2+, and H2O, whereas its 4 products are ADP, phosphate, cob(II)yrinic acid a,c-diamide, and H+. The aerobic cobalt chelatase (aerobic cobalamin biosynthesis pathway) consists of three subunits, CobT, CobN () and CobS (). Cobalamin (vitamin B12) can be complexed with metal via the ATP-dependent reactions (aerobic pathway) (e.g., in ''Pseudomonas denitrificans'') or via ATP-independent reactions (anaerobic pathway) (e.g., in ''Salmonella typhimurium''). The corresponding cobalt chelatases are not homologous. However, aerobic cobalt chelatase subunits CobN and CobS are homologous to Mg-chelatase subunits BchH and BchI, respectively.〔 CobT, too, has been found to be remotely related to the third subunit of Mg-chelatase, BchD (involved in bacteriochlorophyll synthesis, e.g., in Rhodobacter capsulatus).〔 This enzyme belongs to the family of ligases, specifically those forming nitrogen-D-metal bonds in coordination complexes. The systematic name of this enzyme class is hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming). Other names in common use include hydrogenobyrinic acid a,c-diamide cobaltochelatase, CobNST, and CobNCobST. This enzyme participates in porphyrin and chlorophyll metabolism. == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cobalt chelatase」の詳細全文を読む スポンサード リンク
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